The organism is a yeast much in the same vein as candida in that it can disrupt the essential microflora community within the human digestive system. Here, we report the crystal structure of rrqr and the structurebased mutational analysis. Rhodotorula is a common environmental yeast that is found in air, soil, lakes, ocean water, milk, and fruit juice. This distinctive color is the result of pigments that the yeast creates to block out certain wavelengths of light 620750 nm that would otherwise be damaging to the cell. They are frequently isolated from air, fruit juice, dairy products, soil and water. Rhodotorula species are pigmented basidiomycetous yeasts in the family sporidiobolaceae 21. Automated systems were unable to report a species for eight 7% isolates two by vitek 2, four by microscan, and two by a system whose method was not reported. Rhodotorula rubra is a yeast of low virulence which produces a mucoid colony that could be deep coral to salmon pink fig. Rhodotorula rubra 3 56 e7, e15, e30 blastomyces dermatitidis 1 2 e2 trichosporon cutaneum 1 8 e16 penicillium sp 1 8 e16 cladosporium sp 1 1 e16 phialospora sp 1 1 e16 mycobacteria m. Endophytic yeasts of genus rhodotorula are gaining importance for their ability to improve plant growth.
The purpose of this study was to report a case of skin infection caused by rhodotorula rubra in the groin of a 32yearsold hiv infected homosexual male, which lasted approximately five. Yeast, identification, its, rhodotorula, sporidiobolus udc 632. Central venous catheterrelated rhodotorula rubra fungemia. It is readily identifiable by distinctive orangered colonies when grown on sda sabourauds dextrose agar. Unknown but in general terms is an infrequent agent of fungal infections in humans. Pdf the genus rhodotorula consists of a diverse group of. The diagnosis was confirmed by the isolation of the fungus from the csf. Chiral molecule r3quinuclidinol, a valuable compound for the production of various pharmaceuticals, is efficiently synthesized from 3quinuclidinone by using nadphdependent 3quinuclidinone reductase rrqr from rhodotorula rubra.
The yeast was isolated from repeated blood and urine cultures and identified as rhodotorula rubra on the basis of macroscopic and microscopic features. In particular, nitrification the conversion of ammonia to nitrate plays a role in global climate changes, affecting the bioavailability of nitrogen in soil and contributing to eutrophication. To investigate the lifestrategy of the yeast from a genomics perspective, we used. Heterogeneity of the genus has made its classification difficult with five varieties having been recognized. Thus, the effectiveness of certain sorbents against various metals must be tested for optimal results. Rhodotorula rubra fungaemia in an immunosuppressed patient. Considering that rhodotorula is an ubiquitous and saprophytic fungus, the isolation of rhodotorula from nonsterile human sites, especially from the mucous membranes, has often been of questionable clinical significance. However, not all yeasts have the same capability or sorb to the same extent. Algal cultures form colonies of cells that are extremely easy to visualize for better understanding of cell walls and. Other names i cbs 316 dbvpg 7019 hodotorula mucilaginosa ifo 0890 ifo 0909 more. Rhodotorula mucilaginosa was the species most frequently. Rhodotorula species are common environmental basidiomycetous yeasts, which can be found in soil, ocean and lake water, fruit juice and milk, and on shower curtains and toothbrushes. Central venous catheterassociated fungemia due to rhodotorula. Rhodotorula mucilaginosa old name rhodotorula rubra natural habitat.
Pulmonary disease consistent with invasive fungal pneumonia was not apparent for any patient. Mannan produced by rhodotorula is useful for serological diagnosis for leptospirosis a bacterial disease carotenoid production for the food industry. This page was last edited on 16 february 2014, at 20. Case report fungemia due to rhodotorula mucilaginosa in an immunocompetent, critically ill patient jesua. Rhodotorula species are imperfect basidiomycetous yeasts belonging to the family cryptococcaceae and are widespread throughout nature. A unique case of rhodotorula rubra transient fungemia in a postchemotherapy, febrile neutropenic patient with colon cancer, suffering from gastrointestinal mucositis, is described.
The effects of media supplementation with urea nitrogen or the commercial nutrient called nitrofos kl was also verified. Rhodotorula is a genus of imperfect pinkcolored yeasts of the family cryptococcaceae, subfamily rhodotorulodae, which grow as globose budding fungi 1. The genus contains 37 species, of which only three, including r. Between march and june 1988, rhodotorula rubra was isolated from the bronchial washings of 30 of 56 54% patients undergoing bronchoscopy at a north carolina community hospital. An rhodotorula rubra in nahilalakip ha genus nga rhodotorula, ordo nga sporidiobolales, classis nga microbotryomycetes, divisio nga basidiomycota, ngan regnum nga fungi.
Separation and identification of phenol and protocatechuic acid pca metabolites were carried out using high performance liquid chromatography hplc and gas chromatographymass spectrometry gcms. Localised infections without fungemia including endophthalmitis, onychomycosis, meningitis, prosthetic joint infections, and peritonitis usually associated with continuous peritoneal dialysis have been reported in immunocompromised and immunocompetent patients. Rhodotorula is a genus of unicellular pigmented yeasts, part of the division basidiomycota. Improving carotenoid pigments production in rhodotorula. All you need to know about rhodotorula yeastinfection. It can be cultured from soil, water, milk, fruit juice, and air samples. Uncommon yeast infections in hematological patients medscape. Rhodotorula mucilaginosa by rachel adams sometimes the invisible things in your home become visible, and you rather wish they wouldnt. Rhodotorula rubra cause of eye infection, mycoses 10. Another common feature shared by these two yeasts are that rhodotorula, like candida, is now known to be opportunistic which makes it particularly dangerous. Aromatic degradation in yeast rhodotorula rubra water. Rhodotorula mucilaginosa was the most common species of rhodotorula fungemia, followed by rhodotorula glutinis.
Terrestrial and aquatic, including marine habitats. Screening of rhodotorula yeast for high carotenoid production. This is an updated paper focusing on the general epidemiological aspects of rhodotorula in humans, animals, and the environment. There are few studies in the literature on the susceptibility rhodotorula against antifungal drugs. In 811 cases 73% with complete microbiological identification rhodotorula mucilaginosa was the implicated yeast while in the rest rhodotorula glutinis was isolated. Rhodotorula rubra cause of eye infection rhodotorula rubra cause of eye infection segal, esther. Following treatment with amphotericin b, the patients condition improved and the cultures became sterile.
Rhodotorula rubra fungaemia in an immunosuppressed patient rhodotorula rubra fungaemia in an immunosuppressed patient papadogeorgakis, h frangoulis, e papaefstathiou, c katsambas, a. Original carotenoid production by rhodotorula rubra. It can be found almost everywhere from air and fruit through to soil and, although its existence has long been known, it is only very recently that it has been established as a pathogen emerging as a causation of disease. The purpose of this study was to report a case of skin infection caused by rhodotorula rubra in the groin of a 32yearsold hiv infected homosexual male, which lasted approximately five months. Today, the genus contains 46 species of which three have been described as rare human pathogens.
A fatal case of meningitis due to rhodotorula mucilaginosa in a 28 yearold hivnegative male with a history of hodgkin lymphoma who underwent salvage chemotherapy is presented. A case of onychomycosis caused by rhodotorula glutinis. Rhodotorula species are ubiquitous saprophytic yeasts that can be recovered from many. We report the case of a patient who, following surgical removal of an extensive tumour of the bowel, developed fungaemia.
Some factors affecting the production of carotenoids by. Rhodotorula definition of rhodotorula by medical dictionary. Transient fungemia due to rhodotorula rubra in a cancer. We report two cases of central venous catheterrelated rhodotorula rubra fungemia that occurred in patients with acute myeloblastic leukemia. Aromatic degradation by two yeast strains of rhodotorula r. Rhodotorula mucilaginosa is a common airborne contaminant of skin, lungs, urine and faeces. Harrison, transactions of the royal society of canada. Rhodotorula rubra endophthalmitis in an hiv positive patient. The yeast was isolated from repeated blood and urine cultures and. This yeast has a strong affinity for plastic, having been isolated from various medical equipments, such as dialysis equipment, fibreoptic bronchoscopes, and other environmental sources, including shower curtains, bathtubs, and. H033bogota, colombiapontificia universidad javeriana. Rhodotorula species are ubiquitous saprophytic yeasts that can be recovered from many environmental.
Jul, 2019 rhodotorula species considered as an important agent for invasive infection among immunocompromised patients. It is able to scavenge nitrogenous compounds from its environment remarkably well, growing even in air that has been carefully cleaned of any fixed nitrogen contaminants. Files are available under licenses specified on their description page. There are few reports of bloodstream infections due to r. Both amphotericin b and flucytosine have good activity against rhodotorula in vitro, whereas fluconazole is inactive. Rhodotorula mucilaginosa was the most common species of fungemia. The genus rhodotorula includes eight species, of which r. Rhodotorula species are ubiquitous saprophytic yeasts that can be recovered from many environmental sources.
An rhodotorula rubra in uska species han fungi in nahilalakip ha divisio nga basidiomycota, ngan nga syahan ginhulagway ni schimon, ngan ginhatag han pagkayana nga asya nga ngaran ni francis charles st. The selected isolate was grown in synthetic medium to study the effect of carbon to nitrogen ratio, sources of nitrogen and carbon, mineral salts and incubation temperature on carotenoids. Live specimens are used for a wide variety of studies including studying the physiological effects of drugs on a specimens heartbeat and temperature on metabolism, the locomotion of microscopic organisms, and studying plant respiration, photosynthesis, plosmolysis, and more. Pdf rhodotorula rubra causing skin lesions in a hiv. Previously considered nonpathogenic, rhodotorula species have emerged as opportunistic pathogens that have the ability to colonise and infect susceptible patients. Find, read and cite all the research you need on researchgate. Nrrl y1591 cbs 330, mucl 30590, vkm y340, vkm y80 application. This is usually due to saprophytic colonisation of catheters or dialysis machinery and removal of the source of contamination usually leads to clearing of the symptoms. Rhodotorula mucilaginosa jgtas1 was isolated as an endophyte of typha angustifolia and promoted growth in the host. Here we present a case of an hivpositive patient who presented with oral ulcers caused by rhodotorula mucilaginosa, which to our knowledge has not been reported in the literature. Rhodotorula rubra is a common airborne contaminant of skin, lungs, urine and feces. The final diagnosis was confirmed by isolation of rhodotorula rubra from cerebrospinal fluid on culture.
Meningitis caused by rhodotorula rubra in an hivinfected. A 45yearold hivpositive patient presented to the internist with complaints of nonhealing oral ulcers and white patches in the mouth of 2 months duration. In this paper, the rhodotorula diobovata dsbca06 was investigated for growth kinetics on nitrite, nitrate, or. On your shower curtain, on the bathtub grout, or even on your toothbrush, there might be a pink film slowly expanding and adding a little decorative color to your life. A new yeast strain isolated from pin cushion flower scabiosa atropurpura in our laboratory was selected from 200 yeast isolates as carotenoids producer and identified as rhodotorula glutinis var. The median age of the affected individuals in the current analysis was 35 years old iqr. The purpose of this study was to report a case of skin infection caused by rhodotorula rubra in the groin of a 32yearsold hiv. However, all signs and symptoms of the infection disappeared, without antifungal treatment, as soon as neutropenia and mucositis, both of short duration, resolved.
Rhodotorula yeast was grown in 50 ml of basal broth bb 4 gl yeast extract, 1 gl kh 2 po 4, 0. Risk of fungemia due to rhodotorula and antifungal susceptibility. The disease usually occurs in hiv negative immunosupressed middleaged males. Case reportmeningitis caused by rhodotorula rubra in an human. Pseudoepidemic of rhodotorula rubra in patients undergoing fiberoptic bronchoscopy volume 10 issue 11 karen k. Rhodotorula species considered as an important agent for invasive infection among immunocompromised patients. Three novel species, which are nonpathogenic to humans, have. Rhodotorula species are common airborne contaminant fungi and also considered as normal inhabitants in the skin, lungs, urine and feces in humans. Request pdf on sep 1, 2003, s verghese and others published rhodotorula rubra. Identification of different species of rhodotorula using internal transcribed spacers mona abd elmageed mohamed, asharf bakery abdelrazik and samir abdelaziz ibrahim department of genetic, faculty of agriculture and ain shams centre for genetic engineering and biotechnology, ain shames university, cairo, egypt. All structured data from the file and property namespaces is available under the creative commons cc0 license. The fungus is a common colonist of animals, foods and environmental materials.
Physiological and phylogenetic characterization of. Infections due to the yeast rhodotorula are rare in humans. The nature of their interaction with plants, however, remains unknown. Rhodotorula glutinis is the type species of the genus rhodotorula, a basidiomycetous genus of pink yeasts which contains 370 species. Storage in distilled water is an easy and sometimes a suitable means of preserving a yeast culture mcginnis et al. Reviewing the literature we identified cases with central nervous system infection due rhodotorula spp. Identification of different species of rhodotorula using. Rhodotorula mucilaginosa an overview sciencedirect topics. Rhodotorula species is generally not considered pathogenic in immunocompetent individuals, though cases with rhodotorula infections have been reported in immunocompromised patients and patients on central venous catheter. Among the few references to the pathogenicity of rhodotorula spp.
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